Journal: Cytometry. Part B, Clinical cytometry
Article Title: Characterization of myelodysplastic syndromes hematopoietic stem and progenitor cells using mass cytometry.
doi: 10.1002/cyto.b.22066
Figure Lengend Snippet: FIGURE 4 Boxplots exemplifying the expression levels of selected markers in selected analysis I metaclusters from the healthy bone marrow reference grid over sample types. Statistics are given in Table 3. (a,b) depicts the significant differential expression of HSPC markers CD49f and CD34, respectively over samples types (AML, HR-, LR MDS, and HBM) in HBM reference analysis I metacluster 9. (c,d) show the significant reduced expression levels in MDS samples for intracellular markers pCREB and IkBa, respectively in HBM reference analysis I metaclusters. (e,f), respectively show two examples of aberrant CD44 expression in HBM reference analysis I metacluster 19 and aberrant reduction of CD200 expression in MDS samples in analysis I metacluster 3 [Color figure can be viewed at wileyonlinelibrary.com]
Article Snippet: ITK-Diagnostics 329702 170 Er CD45RA Core GMP marker HI100 Fluidigm 3170010B 171 Yb pErk Differentially expressed on AML SC versus normal stem cells D13.14.4E Fluidigm 3171010A 172 Yb pS6 Differentially expressed on AML SC versus normal stem cells N7-548 Fluidigm 3172008A 173 Yb CD371 Aberrant in AML SC 50C1 Fluidigm/BD 3173007B 174 Yb CD279 (PD-1) Upregulated in AML/MDS-experimental EH12.2H7 Fluidigm 3174020B 175 Lu CD34 Core HSPC marker 8G12 BD Biosciences 348050 176 Yb pCREB Differentially expressed on AML SC versus normal stem cells 87G3 Fluidigm 3176005A 209 Bi CD47 Upregulated on MDS progenitor cells CC2C6 Fluidigm 3209004B nloaded from https://onlinelibrary.w iley.com /doi/10.1002/cyto.b.22066 by C ochrane Israel, W iley O nline L ibrary on [05/11/2022].
Techniques: Expressing, Quantitative Proteomics